Of course it depends on the engine with it's specs and the exhaust design. However what I said isn't hearsay it's according to the official quoted numbers from TODA on both of their offerings, a workshop and the direct result of a guy I know. The workshop was IDB auto with one of the earlier generation of engines of 3sge that was a quad throttle race engine. They found with testing the 4-2-1 design made more power even up top.
So while I am sure there may be exceptions for under circumstances it seems overwhelmingly that's not the case.